Evenity….stopped after the first set of injections…

My primary focus has been Evenity and Prolia since this was the route of my planned treatment which has been reset. Amgen chooses to use the Relative Risk Reduction to overstate the efficacy. For example, according to Amgen, studies on fracture risk in women taking Evenity has an Absolute Risk Reduction of 1,3% and an RRR 73%. Amgen chooses to market the 73% RRR making it sound as though the drug reduced reduction of spinal fractures by 73% when the drug has truly an ARR of 1.3% (dropping from 1.8% to .5%). That minimal absolute reduction in fractures is hardly worth taking a drug with such potential brutal side effects. And because Evenity is so new…who knows what the long term effects of this drug are other than what Amgen has already stated that you could have atypical femur fractures, osteonecrosis of the jaw or an increased risk of death from cardiac events. Perhaps other drug developers use the same overstatement of benefits; however, I have not reviewed them. When I agreed to Evenity, the 73% RRR sounded amazing. After my awful experience with my first injections, I dug deeper. Take a look at the Evenity website. It states “Proven to reduce spine fracture risk by 73%.” In much smaller print below this claim, it explains the actual ARR position “women receiving Evenity had fewer new spine fractures (0.5%) than women receiving placebo (1.8%).” Take a few moments to familiarize yourself with RRR and ARR. Interesting info!

Wow, that’s quite a difference in percentages. Evenity is what my doctor wants me on also. What are you considering instead of Evenity.

My primary focus has been Evenity and Prolia since this was the route of my planned treatment which has been reset. Amgen chooses to use the Relative Risk Reduction to overstate the efficacy. For example, according to Amgen, studies on fracture risk in women taking Evenity has an Absolute Risk Reduction of 1,3% and an RRR 73%. Amgen chooses to market the 73% RRR making it sound as though the drug reduced reduction of spinal fractures by 73% when the drug has truly an ARR of 1.3% (dropping from 1.8% to .5%). That minimal absolute reduction in fractures is hardly worth taking a drug with such potential brutal side effects. And because Evenity is so new…who knows what the long term effects of this drug are other than what Amgen has already stated that you could have atypical femur fractures, osteonecrosis of the jaw or an increased risk of death from cardiac events. Perhaps other drug developers use the same overstatement of benefits; however, I have not reviewed them. When I agreed to Evenity, the 73% RRR sounded amazing. After my awful experience with my first injections, I dug deeper. Take a look at the Evenity website. It states “Proven to reduce spine fracture risk by 73%.” In much smaller print below this claim, it explains the actual ARR position “women receiving Evenity had fewer new spine fractures (0.5%) than women receiving placebo (1.8%).” Take a few moments to familiarize yourself with RRR and ARR. Interesting info!

Many meds use relative risk. I am often puzzled because although relative risk shows seemingly minor changes in bone density, many osteoporosis meds do seem to bring significant improvements to DEXA scores.

The risk of femur fracture and jaw necrosis are lower with Evenity than with bisphosphonates or Prolia. I have been told by my doc that most cases of those side effects are for cancer patients with much higher doses. Cardiac risks are for those with preexisting issues, I believe. Check all this out with your doc!

Wow, that’s quite a difference in percentages. Evenity is what my doctor wants me on also. What are you considering instead of Evenity.

Hi again sedrake 51. Just read your post about the negative reaction to Evenity. I am trying to adhere to good diet, exercise, and supplements in the hope that they will help my Dexa scores/my bones. I shall have to rethink my options if this doesn't work. The black box warnings highly discourage Evenity. It is too bad that regardless of what we take, we have to continue for the rest of our lives. Or it regresses. Tsk.
Thank you for sharing your sufferings. It is most generous of you.

@lashu you might want to look into the reasons for the black box warning. When compared with placebo, one study I read said that there was no increase in cardiovascular events with Evenity, but when compared with alendronate, Evenity has more. One reason might be that alendronate has a preventive effect so comparions with Evenity might make Evenity's risks look higher. Again, I read this and don't know the date or the most recent research on this. Maybe your doc can explain.