John - Once again, I think your insight on PN is dead on. The "even knowing the cause is not going to help you find a cure" is exactly right. And, with PN, that is the probably as hard to accept as the pain and numbness and balance issues we live with each and every day. I've expressed this in the past that sooner or later, one realizes that living our life the best we can makes more sense than chasing the reason why we ended up with PN. We wake up each day with this rotten disease and that isn't going to change but what can change is how you choose to live with PN, dealing with it and find things that work offering SOME relief.