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Mesenteric Panniculitis or Sclerosing Mesenteritis

Digestive Health | Last Active: Nov 6 8:25am | Replies (1517)
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@kimh

Thanks for sharing. All of our cases may be a little different than one another, but there are always similarities. Funny about the shingles. I've been getting the vaccine to prevent getting shingles due to prolonged dosage of prednisone (since August 2017). I am also having a very difficult time weaning off prednisone, relapsing time and again. My new regimen is to stay on 5 mg. daily until I have reached full remission for 4-6 weeks. After that, we will try to wean down off the prednisone. It really is disheartening to be continually relapsing. Maybe some people just have a harder time weaning off prednisone than others?

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Replies to "Thanks for sharing. All of our cases may be a little different than one another, but..."
mp333 | @mp333 | Jun 12, 2019

Yes thats what I was also trying to do: to get to a lowest dose prednisone as possible to modulate the immune system response. At first I thought 12mg then I tried 5mg but always 2-4 weeks later relapse.
My take on MP is that it is an immune response to something, and then should naturally go away but becomes autoimmune as the immune system/mesentery or underlying condition doesnt settle or be removed. Therefore prednisone provides immune modulatory therapy. Pregabalin also has shown an immune modulatory effect - its in the literature. I would suggest discussing using pregabalin with your doctor maybe. Pregabalin is also used for anxiety and seems to have none or little side effects as opposed to prednisone.

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