I was very nervous about starting the Big 3 but I have now been on them for 1 month and only had a little stomach upset for 1 day. I definitely spaced the meds apart so I could tolerate them better. I take Azithromycin and Ethambutol in the morning with breakfast. I then take Rifampin right before bed on an empty stomach. No problems so far. I took the advice of many in the group and got a LifeStraw Pitcher and LifeStraw Water Bottle along with the Bololo Baby bottle sterilizer for all my equipment (No more boiling it) and such a time saver. Everyone reacts differently to the meds and once you get on a schedule for everything much of the stress goes away.