I had the common side effects of increasing sensitivity to cold, neuropathy in the fingers and feet from oxaliplatin, and diarrhea from the Irinotecan. I never experienced nausea of vomiting and my appetite was very good throughout the 24 months I received chemo.

The neuropathy in the fingers cleared within a year of finishing the treatment. The feet took much longer. I did not notice improvement until 2.5 years after finishing Folfirinox. From that point improvement was slow and fairly steady. it took 7.5 years to fully resolve but I had a very good quality of life despite the neuropathy and made adjustments. Gabapentin relieved any discomfort I experienced. For me, any discomfort from doing Folfirinox was well worth doing it as it contributed to being declared not only NED in 2016 but now cured of stage IV disease.