@krcc Thank you for sharing your experience. I have been having similar symptoms and health problems. I was finally diagnosed after my bloodwork results were positive for RNP autoantibodies. The first ANA test was a false negative. My hematologist reran some labs including ANA and it was positive. So, she did further testing and I have high levels of RNP. I have been experiencing heart arrhythmia, peripheral neuropathy, terrible lumbar spine pain as well as pain/stiff joints all over. It seems to be affecting my kidneys over the last 2 years, my heart (also believed to have caused my Aortic Aneurysm which was discovered 5-6 years ago), my lungs, and entire GI tract.