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Anyone here with Hurthle Cell (Oncocytic) Carcinoma?
Thyroid Cancer | Last Active: Jan 19 8:13am | Replies (62)Comment receiving replies
@paul300, thanks for jumping in to question the accuracy of HTC spread. I did some more digging and found conflicting information.
"Hurthle cell thyroid cancer is now defined as a follicular thyroid cell “derived” cancer and not a variant of follicular cancer itself."
- Hurthle Cell Thyroid Carcinoma https://www.ncbi.nlm.nih.gov/books/NBK568736/
"Hurthle cell cancer can spread into the lymph nodes of the neck. In fact, at least 20% of hurthle cell cancers will have spread to neck lymph nodes on their initial presentation." https://www.thyroidcancer.com/thyroid-cancer/hurthle#:~:text=Hurthle%20cell%20cancer%20certainly%20can,nodes%20on%20their%20initial%20presentation.
"About 20–30% of HCC cases have metastatic extension at the time of initial treatment. The most frequent sites of metastasis are the lungs and bones." https://academic.oup.com/qjmed/article/112/6/453/5255882
"Hürthle cell carcinoma (HCC) is a rare tumor that tends to metastasize to the lymph nodes." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931345/
You won't be able to share links yet because you're a new member. But maybe you can tell me where to look for further information about typical spread for HCC. It is confusing. Do you have metastatic HCC?
Replies to "@paul300, thanks for jumping in to question the accuracy of HTC spread. I did some more..."
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Hi Colleen,
Thanks so much for your reply. While I will have to retrace my steps to find specific information (often conflicting as the source then becomes more important) as to HCC spread, I did find this statement in the Clayman Thyroid Center article:
"Hurthle cell cancer has a greater risk of growing into blood vessels in and around the thyroid. This is called angioinvasion. This occurs, in fact, more frequently than hurthle cell cancer spreads to lymph nodes."
So, yes, as you point out, there is most certainly lymph node involvement in HCC spread but angioinvasion is seen as well. I don't think this statement clarifies where HCC tends to spread first.
If I find more information about this, I'll post it here. Thanks again, Colleen.