My husband (Gleason 8, 45 sessions of RT) has been getting degarelix injections monthly for the last 12 months.
This blocks testosterone the same way as Orgovyx but is less expensive and more painfully administered.
Near zero testosterone has lots of side effects. My husband increased his magnesium supplements to get relief from nightly leg cramps. He takes calcium/vitamin D plus vitamin K2 to protect his bones. His red and white blood cells and platelets are just below normal. Iron won’t help as it is an androgen receptor issue, that is no testosterone.
Hot flashes still a nightly issue as well as daytime. He now abstains from alcohol and layers his clothing to mitigate the hot flashes.
He has 12 more monthly injections to go, but there is no sign of recurrence. Which is why he puts up with the side effects.