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Ultrasensitive PSA Test Post RP

Prostate Cancer | Last Active: Jan 10, 2023 | Replies (40)

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@jcrist1027

Finally I should note there is such a thing (as mentioned by one user here) as "persistent PSA" after RP. I don't think it's that common but you could have a PSA in the 0.03 to ~0.15 range that remains in that range indefinitely, also termed by another user here as "stable PSA". This throws a monkey wrench into making early salvage treatment decisions. I had bilateral nerve sparing and am at 7 months post RP and my erections are slowly coming back (were a 10/10 pre-RP and at 7 months I'm at about a 5-6/10 erection and Urologist says I will eventually recover to a 9/10 (I'm only 54 years old.) BUT, if I do salvage radiation, that will be the nail in the coffin as far as achieving erections due to the blood vessel damage from the radiation, so no erections without a pump, injections or high-dose Viagra/Cialis (which may not be enough.) I think personally I would error on the side of caution and assume BCR at 0.03 and go for early salvage therapy for a higher chance of cure at the expense of significant permanent loss of EF. Versus waiting several months to see if my PSA will stabilize while the micro-metastatic cancer cells could be spreading farther out beyond the field of radiation during that time. Your EF is a moot point when you're on ADT, Chemo or are dead.

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Replies to "Finally I should note there is such a thing (as mentioned by one user here) as..."

You commented - I had bilateral nerve sparing and am at 7 months post RP and my erections are slowly coming back (were a 10/10 pre-RP and at 7 months I'm at about a 5-6/10 erection and Urologist says I will eventually recover to a 9/10 (I'm only 54 years old.) BUT, if I do salvage radiation, that will be the nail in the coffin as far as achieving erections due to the blood vessel damage from the radiation, so no erections without a pump, injections or high-dose Viagra/Cialis (which may not be enough.)

I had SRT in March 2016 after BCR. I too had nerve sparing surgery. My radiologist counseled me about the possibility of the radiation treatment causing ED. In my case, study of one, did not. Why not, who knows, study of one though. I do believe the improvement in the planning software and delivery of the radiation over the years may be a factor.

Kevin