Hello, I'm sorry you are having issues with the second cycle. I do hope things get better as you continue the process. I had a miserable several days during my second week, so the doctor recommended using a stool softener (as opposed to a laxative), and I added about 1/4 cup of prune juice (warmed). A neighbor who is a retired nurse told me how she dealt with patients in the hospital who had constipation, and the doctors used Colace gentle stool softener and a little warmed prune juice as I mentioned above. Just once a day, but it also takes a couple of days to get things moving. That did provide much needed relief. She also told me it is better to warm up your water and fluids before drinking because it helps warm up the colon. I've been doing that too. I started my week off as of today, and am so glad constipation problem has been resolved for the moment. I spoke with my oncology nurse this morning who said when I start the next cycle, I can take a stool softener daily to prevent the constipation, so I may do that after the first day and see how my system reacts. I just don't want to cause the opposite problem. I may check with the chemo nurse on this. Let me know how things are going as you continue this cycle, and I will let you know how I am doing when I start again next Monday. All the Best!