I stopped 20 years of Metformin use in August 2022 after YEARS of food "sensitivities" too numerous to list that caused diarrhea, bloating and nausea. Once I stopped the Metformin, my food "sensitivities" dramatically stopped! I could even tolerate milk products! Definitely long term use of Metformin could be linked with severe gastro issues. It was my endocrinologist that told me to stop Metformin immediately when I told her about my severe gastro issues. I never told her because I didn't think gastro issues were a concern for a diabetes doctor. Who knew??