I just ended a year of lupron and Erleada treatment and Surgery and the fatigue issues and sleep disorder has ceased and I now feel much better. That said, this treatment was not terrible, I was able to drive to UCLA hospital each month ( 1.5 hours each way ) and the treatment successfully reduced my testosterone to 12 and PSA to .01. You have to do whatever you can to cure or control the cancer and the above was super aggressive and successful for my Gleason 9 aggressive advanced castration resistance prostrate cancer. Good luck to you!