I guess I've had both if you consider the radiation I had to the prostate/surgical bed, 39 treatments and still on orgovyx for hormone therapy.

The only thing I really noticed with the treatments is my butt, anus I guess, got sort of sore. Irritated might be a better word. I only had one small bout of diarrhea for about 2 days. At the end of the treatments, say last 10ish days I started to get somewhat tired. I would workout after my morning radiation session but it took a really strong effort to get through those. Then it was a power nap when I got home. It took about 2 weeks before I started to notice improvement after the treatments were over. Now, back to normal as far as I can tell.

The orgovyx is really, really, really annoying. I have very little to no libido and testicles the size of black beans. I had "restless leg" syndrome when I started it and got strong hot flashes several times a day. At about 2 to 3 mos the restless legs disappeared and now at 6 mos I noticed the hot flashes have diminished greatly. I think I only notice a couple a week, usually during the day now. I guess your body gets somewhat used to it.

There are some potential issues with any hormone therapy like raising your cholesterol, blood sugar etc. I haven't had a full blood panel done yet, that's coming in the next couple months. I want this to aid in my decision to continue the hormone therapy or drop it early. I'll post if it shows the orgovyx caused any issues there.