I took that chemo for 6 weeks five days a week. I was fatigued, but getting around doing the basic basics not so bad.. I was also taking the radiation 5 days a week for 6 weeks. If no radiation I would expect it to be manageable but weak weak for sure.. best of recovery! My big day comes on the 18th of Jan. Hope and pray for a healthier rectum. Was at 6cm. Maybe much smaller if at all ?