@kaptainkat That is what I have been told by pain doctors as well. Sciatica is usually caused by nerve pain due to an endless number of factors. I also have bone spurs and DDD and I relieve pain from that differently from sciatica.

The quality of pain can be different but other pain types can be persistent and severe. Bruises and sprains are considered to be acute, but a sprain, if still painful after 12 weeks and with medical treatment, would be considered persistent pain, which is what the industry is calling chronic pain. It doesn't matter if it is nociceptive, neuropathic, nociplastic, or whatever. It's simply pain that persists despite treatment and/or beyond typical healing time. Cymbalta is "thought" to disrupt nociceptive signals as well as chemicals in the CNS per the research I read when Rx'd this med. Persistent migraine, in a class all its own, is another example of non-neuropathic pain that is disabling. It is not yet known what trigger points are and why they cause pain but the can cause severe chronic pain and disability. The point is that depression and anxiety is common in people with persistent pain no matter what the cause. There's plenty of research going back decades on pain's effect on mental health and the use of antidepressants for pain.