Welcome @irened, I also take supplements for my idiopathic small fiber peripheral neuropathy but I only have the numbness and some tingling and no pain. I posted my story in another discussion here - https://connect.mayoclinic.org/comment/310341/.

There are a lot of different supplements that have shown helpful for relieving neuropathy symptoms. There are no cures but if they help with the pain that makes for a much better quality of life. The Foundation for Peripheral Neuropathy has a list of supplements shown to help with neuropathy on the website along with other complementary and alternative treatments here - https://www.foundationforpn.org/wp-content/uploads/2020/08/Complementary-and-Alternative-Treatments-Revised-2020-final.-1.pdf

I thought I would share a link to a small pilot study on agmatine in case you haven't seen it.
-- Evidence for Dietary Agmatine Sulfate Effectiveness in Neuropathies Associated with Painful Small Fiber Neuropathy. A Pilot Open-Label Consecutive Case Series Study:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071502/

I always wear long diabetic loose fit socks at night to help keep my feet feeling a little better.
Have you tried any other supplements or treatment to help with the cold sensation in your legs?

@irened Hi irenD Can you please let us know if the Agmatine ends up helping with your nerve pain? PEA seems to be helping mine in combination with protocol 525 that the Mayo mentors have given us information about.

I take Gabenpentin for nerve pain but nothing will help with coldness but a heating pad. If it weren’t for the medicine I would be in bad shape.