Found this forum as I was trying to alleviate my worry from a positive Cologuard test. I am 45 and this was my first testing for this sort of thing. When they called me they just said it was positive for either blood and/or altered DNA but cant say which it is. The follow up "dr" they have you can chat with says that blood is unlikely due to hemorrhoids (but I have seen the opposite on other health websites). Either way, I do have my first Colonoscopy scheduled for Friday. Wish I had never done the Cologuard test and just stuck with the Colonoscopy because now I am truly worried especially with so many people dying from Colon cancer in the news the last few years.