Hello cblue. I have had GERD since 2015. I was on omeprazole 40 mg for a year and since then 20mg daily. It really works! I also invested in an adjustable bed that raises my head (and legs). I sleep like a baby and my reflux doesn't bother me at night. If you can't afford to invest in an adjustable bed, use a wedge or multiple pillows to elevate your head. You will get a lot of relief with the omeprazole, but also watch what you eat. Certain foods can trigger acid reflux. I hope this helps and I wish you well.