Hi John,

Thanks for the hint about metabolic syndrome. My expanding waistline during covid isolation/inactivity fits this picture.

Otherwise, in my search for answers, I recently came across a published paper on B6 toxicity which might be of interest:
https://www.sciencedirect.com/science/article/pii/S221343442030013X
It used a very small cohort but even so found some individuals for whom B6 quickly accumulated to toxic levels.
(It did not accumulate for most volunteers.)
Another interesting point to note from the study is that the normal method of testing for B6 in the blood does not actually test for pyridoxine but instead for PLP. It was the pyridoxine that accumulated and caused problems.

John