From a physiological point the swelling places pressure between the skin in the tissues which in turn puts pressure on your vessels, nerves, muscles as well. If the edema goes unchecked and backs up to your groin area you’re on your way to potentially more serious issues. So reducing the edema does play a very large part if you’re experiencing this in addition to already diagnosed PN. Also, I n addition to weight gain Lyrica causes peripheral edema. There’s always a trade off unfortunately.
I have PN but no edema. I’ve found that if I stretch before bed and keep my feet and legs warm at night it reduces my incidents of cramps and pain. I take oral Baclofen for spasms and buprenorphine patch, THC, CBD for pain and I’m off oxycodone completely.