1. < Breast Cancer

Estradiol levels with AI

Posted by cashemire @cashemire, Dec 5, 2022

Since a recent study (May 2022) found that estradiol was lowered similarly whether the AI (exemastane) was taken daily or every other day, does anyone know what is the aimed at level of estradiol when taking AI ? And can they confirm a blood test would allow one to know this?
Thanks!

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cashemire | @cashemire | Dec 26, 2022
In reply to @windyshores "Just to clarify the above: "Tam01 is a phase three trial of low-dose Tamoxifen in women..." + (show)
@windyshores

Just to clarify the above:

"Tam01 is a phase three trial of low-dose Tamoxifen in women with high-risk lesions, including DCIS, atypical ductal hyperplasia and lobular carcinoma in situ."

Note the word "lesions." Some of these are now termed "pre-cancers."

So this study does not relate to invasive cancers that , it seems. Am I missing something?

Also most of us are told that after menopause, we should be on aromatase inhibitors, which are more effective for us than tamoxifen. Or that is what I was told.

I would like to see a study that proves baby Tam works for invasive cancers at this low dose and is still effective for these more severe cancers.

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Yes, you are right, an important distinction but still good news for DCIS etc women on this site.
Also, ever the optimist myself, I like to think this may ultimately be good news for the rest of us as well...some who don't tolerate AIs may have another option without the current adverse tamox effects at some point in the future, if studies on invasive types reveal similar results of lower doses just as effective.

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anjalima | @anjalima | Dec 26, 2022

I think there is an overall trend in less is more. We saw this with the ONCOTYPE DX … saving 70% of Women with BC from a former protocol of chemotherapy … now individuated . Trials now are looking at benefits of radiation and amounts of radiation. And here we see trials on lessening meds. All GOOD FOR US!

Would love more research in IDC and AI’s although I have very very mild side effects I worry about unseen effects like bone loss.

BRAVA RESEARCH PROFESSIONALS

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cynthia09 | @cynthia09 | Jan 10, 2023

Quisiera saber si alguien sabe algo del fulvestrant, ya que fue el que me indicaron después de estar tomando el letrozol, gracias

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1 reply
Moderator
Colleen Young, Connect Director | @colleenyoung | Jan 22, 2023
In reply to @cynthia09 "Quisiera saber si alguien sabe algo del fulvestrant, ya que fue el que me indicaron después..." + (show)
@cynthia09

Quisiera saber si alguien sabe algo del fulvestrant, ya que fue el que me indicaron después de estar tomando el letrozol, gracias

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@cynthia09, here are 2 discussions where members are talking afulvestrant:
- Ibrance and Fulvestrant for Stage 4 MBC, Lung Fills w Fluid https://connect.mayoclinic.org/discussion/ibrance-and-fulvestrant-for-stage-4-mbc/
- Abemaciclib (Verzenio) and fulvestrant (Falsodex) Treatment https://connect.mayoclinic.org/discussion/abemaciclib-and-falsodex-treatment/

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sirene | @sirene | Feb 27 5:02pm
In reply to @windyshores "Again, the study above says side effects were the same for all doses tested. Not sure..." + (show)
@windyshores

Again, the study above says side effects were the same for all doses tested. Not sure how this relates to the other comment in the study about toxicity.

The insert that comes with Femara states that 20% of the dose reduced estradiol below detectable levels. My doc okayed every other day.

The question would seem to be, is estrogen suppression the only reason for side effects? If the study found similar side effects at all doses tested, it would seem so, but that is the question I wondered about.

I don't know if side effects would be better on a lower dose. I didn't have bad ones on the full dose so I stuck with it for 5 years.

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I am on Letrozole, it will be a year at the end of March. I have had my estradiol checked numerous times. My last one was 16 but has been as high as 33 and as low as .68. Who knows what it should be?

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