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Estradiol levels with AI

Breast Cancer | Last Active: Feb 27 5:02pm | Replies (35)

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@windyshores

Just to clarify the above:

"Tam01 is a phase three trial of low-dose Tamoxifen in women with high-risk lesions, including DCIS, atypical ductal hyperplasia and lobular carcinoma in situ."

Note the word "lesions." Some of these are now termed "pre-cancers."

So this study does not relate to invasive cancers that , it seems. Am I missing something?

Also most of us are told that after menopause, we should be on aromatase inhibitors, which are more effective for us than tamoxifen. Or that is what I was told.

I would like to see a study that proves baby Tam works for invasive cancers at this low dose and is still effective for these more severe cancers.

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Replies to "Just to clarify the above: "Tam01 is a phase three trial of low-dose Tamoxifen in women..."

Yes, you are right, an important distinction but still good news for DCIS etc women on this site.
Also, ever the optimist myself, I like to think this may ultimately be good news for the rest of us as well...some who don't tolerate AIs may have another option without the current adverse tamox effects at some point in the future, if studies on invasive types reveal similar results of lower doses just as effective.