Hi Ginger, and thank you.

I have my lab tests for various reasons dating back as far as the year 2000. I took note of them and the trends in the area of eGFR specifically, since this is the malady du jour. The decline actually started at the end of the year 2017, which in February of that year, I had taken the direct acting antiviral, HARVONI, to cure chronic hepatitis c. I used to be an ambulance driver. Now I'm a TV actor.
I was diagnosed with HCV Gt: 1a, in 1990. I had remained treatment naive, since the current treatment was barbaric, at best. My hepatologist, told me to wait on treatment, he knew these DAA's were coming down the pipeline. For over 30 years, my lifestyle choices helped me to maintain some good stasis. My eGFR ranges were maintained at above 90 up until the end of 2017, they dropped to 90, then fluctuated between 60 and 80. My glucose also went up and hovered at about 100-110 for about three years post HARVONI -solo treatment 8 weeks.
I found the monograph of this drug from Canada. It's side effects "correlate" and are mentioned adversely in Ph. III clinical trials, kidney function and elevated glucose, respectively.
So, yes, it will be interesting to see if things improve. As it is, the candle burns at both ends with primary and secondary causes, retention damage from the prostate and from the kidneys, tertiary when including the HCV. I cannot conclude that the DAA was causal, since the prostate issue had been happening since 2013. However, inflammatory responses did elevate after HCV eradication.
You, and the people here have made embarking on this journey very helpful for me and I will share my results across the board here as they relate to each category in the Mayo forum.
A giant whopping hug, from me to you.