I think it has different effects on people. I received Lupron for 25 months. About halfway through the treatment I noticed I had very little energy especially in my and told the urologist I didn't like it and would like to stop it. He said I needed to continue to take it for 2 years so I did. I am now almost 4 years post Lupron, have very little energy, my testosterone is about 15 and will be that or less for the rest of my life and I wish I would have stopped taking Lupron when I initially wanted to. I can't imagine ever agreeing to take Lupron again. However, I think others are not adversely effected by it very much at all.