@healin hand what is your goal here? Are you interested in finding out if the aromatase inhibitors are needed, or what dose is effective? Are you trying to avoid side effects or prove the meds aren't needed?

Read the Femara insert, or the drug insert for any AI. For Femara, the insert basically says that in studies, 20% of the suggested dose reduced estradiol below detectable levels.

But I am not sure whether dose matters anyway. If estrogen is effectively suppressed, at any dose level, the side effects would probably be the same, right?