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Breast Cancer and complementary or integrative therapies

Breast Cancer | Last Active: Aug 5, 2023 | Replies (119)
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@healinhand

This was sent to me from my wife’s oncologist:
Hi guys,

The estradiol test is <10.0 (less than 10) and you are correct that is the bottom limit of the test. The only way to get a more sensitive test would be to send a sample to the Mayo clinic for Mass Spectrometry (https://www.mayocliniclabs.com/test-catalog/overview/81816#Overview) which should be able to detect lower levels of estradiol. However, even if we detect a level on this test, we don't recommend dose adjusting the letrozole.

I think I want to pursue this a little more.

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Replies to "This was sent to me from my wife’s oncologist: Hi guys, The estradiol test is <10.0..."
anjalima | @anjalima | Dec 22, 2022

Interesting and thank you. Please keep us posted. 🌸

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windyshores | @windyshores | Dec 23, 2022

@healin hand what is your goal here? Are you interested in finding out if the aromatase inhibitors are needed, or what dose is effective? Are you trying to avoid side effects or prove the meds aren't needed?

Read the Femara insert, or the drug insert for any AI. For Femara, the insert basically says that in studies, 20% of the suggested dose reduced estradiol below detectable levels.

But I am not sure whether dose matters anyway. If estrogen is effectively suppressed, at any dose level, the side effects would probably be the same, right?

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