My physician said I just needed one infusion. I then continued on Alendronate for 4 more years. My story was that I had to take letrozole for breast cancer, a drug which inhibits estrogen. Right after I started the drug my osteopenia was pushed into Osteoporosis. My values had increased significantly after the Reclast (particularly my spine) in the follow up bone scan about a year later . They continued to increase even after that while I was already on Alendronate again for further 4 years. Now I have been for 4 years on an "Alendronate vacation", and now my values are getting bad again. If you do the Reclast, I would do one and see how it goes. Be aware, you need to fix your teeth before, if you need an extraction or a root canal beyond the tooth's apex you should do it before. Also your calcium will go down at first after the infusion. Have all values checked including PTH. right after.