Well, I've been off caffeine now for over 2 1/2 weeks and no change in my leg cramps or cold feet. I hike a hard and fast 3 miles each day and other than my feet feeling frozen the pain abates. After sitting for any length of time though it returns. The worst is sleeping and then getting up in the morning. No nighttime pain...yet, but it's almost like electric shock waves are piercing through my legs for the first 200 steps or so. Then it subsides a bit. But always with me. My neuropathist is pretty bland about this. I think the reason that there hasn't been more research done is that there's no money in it. Not life threatening, only selling prescriptions. Not nearly as lucrative as bypasses or cancer treatments...what it boils down to. I've been coming to the conclusion that this is as good as it gets and will just have to live with the ongoing pain...bummer, depressing....