Thanks for sharing your story; it is helpful to hear about others going through similar experiences. I have stage 4 colon cancer that had spread to the liver. They removed the masses in my liver and colon, but unfortunately it had spread to other areas.

I have had 13 infusions of Oxaliplatin, 5 in the spring of 2021 and 8 since this August. My experience is that the issues with the cold start fast and furious with the infusion, but start getting less intense after about 6 days and I can usually drink orange juice right out of the fridge with only a little discomfort after about 8 days. I have learned to take smaller sips when drinking anything colder than room temperature.

You are very right about bundling up when going out in the cold. Anything below 50F and my nose and mouth also get the slightly painful tingling, and some mild cramping in my hands. I keep a rechargeable Zippo hand warmer near by even in the house to help with the hands. I'm not looking forward to a Chicagoland winter - let's hope all of us have a short and mild one!