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@colleenyoung

@terradean, sorry that you're dealing with bone pain.
You'e right that chemotherapy damages the DNA of cancer cells, making them unable to survive. This is what makes chemotherapy so effective. Treatment also kills or slows the growth of healthy cells that grow and divide quickly, causingside effects. Side effects often get better or go away after chemotherapy treatment is complete and healthy cells repair themselves.

The mRNA vaccine does not alter DNA however. mRNA delived by injection never enters the nucleus of your cells, where your DNA is kept. It doesn't become part of your DNA. Read more here: https://www.mayoclinic.org/diseases-conditions/coronavirus/in-depth/different-types-of-covid-19-vaccines/art-20506465

I tend to agree with @val64 that Neulasta is the mostly likely cause of bone pain, possibly along with the chemo combo as well. Bone pain is listed as a common side effect of Neulasta Onpro (https://www.drugs.com/mtm/neulasta-onpro-kit.html#side-effects
Paclitaxel and carboplatin, also known as Taxol/Carbo, can cause joint and muscle ache in some people. (https://www.macmillan.org.uk/cancer-information-and-support/treatments-and-drugs/paclitaxel-and-carboplatin)

You mention that your oncologist suggested only taking 1 pill instead of 3. Is that for the dexamethasone? Are they changing the dosage of chemo or Neulasta?

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Replies to "@terradean, sorry that you're dealing with bone pain. You'e right that chemotherapy damages the DNA of..."

My normal dose is 2 of dexamethasone, however, since side effects are bone pain also, stated to Dr. possibly try taking just 1 and see if helps and using Benadryl he recommended at night during that few days. Interesting how have no problems with chemo even drinking my coffee
this morning with milk and tummy just fine. Tomorrow will tell me more. Going to take Benadryl again tonight. Only slept 3 or 4 hrs at a time for about week last to chemo rounds, last night slept normal.

I am sorry, But I never thought mNRA shots did change your DNA just all the gossip regarding them. I have had all that were available to me. I think they change dosage of chemo and Neulasta depending on blood work. What he told me was the reason I was given the dexamethasone is for nausea and since not having any, dropping the dosage may make bone pain less. Just something to try. And, he told me to add Benadryl at night may help with side effects. They give it to me with IV on chemo day. Never said to use before after. Will know more tomorrow. Was just called and simulation for radiation is now set for 12/27 at 10 am.