I did 18 months of Lupron, six 90 day shots. Unfortunately, "mitigation" strategies are generally limited.

For the hot flashes, there are various medications that may mitigate, some say acupuncture. I more or less did small things, never ran the heater in my car, swam in the unheated pool at the gym, went outside on the deck...

The fatigue, I did 18 months of Lupron, exercised as best I could - went skiing in Colorado, hiked in the mountains, rode my bike, went to the gym and used the elliptical, lifted weights, sawm, played basketball...even did the 26,2 mile Bataan Memorial March down in White Sands, NM. Think that helped mitigate the fatigue.

Never lost my libido but testacies and penis shrank to pre-pubescent days. Maybe Cialis or Viagra might have helped (or other penile devices) but in a sexless marriage so wasn't worth the trouble.

I did not have any depression some experience.

Kevin