For what it’s worth, I was on a ADT for almost 11 years. During that time we were never able to get my PSA below 2.0 and periodically it would get up to as high as 10 to 15. About two years ago we added Zytiga (an antiandrogen drug) which helped for a while. Two months ago, I became so tired of having to get injections every three months with Lupron or Eligard, that I decided to have a bilateral orchiectomy. Sadly, my PSA is continuing to rise, up to about 8 now, even with no circulating testosterone, except the little bit that comes from the adrenal glands so I am no longer on ADT, per se. but I am still getting Zytiga. To the best of my knowledge metastatic prostate cancer is not curable so all we can do at this point is try to control it and hope that someday a treatment will come along that can cure it before it takes us down. My oncologist says that prostate cancer cells eventually figure out how to do without testosterone, and/or create their own. Meanwhile, I’m relegated to treatments that will hopefully find and eradicate the existing cancer cells in my body, looking at radium 223, chemo and Pluvecto currently.
My best wishes and prayers go up to all you guys who are struggling with this seemingly never ending battle!