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← Return to Estradiol levels with AI
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@windyshores “ So logically, if estradiol is reduced enough to be effective, side effects would be the same regardless of the dose, right? Because side effects are from estrogen suppression. Including menopause-like effects and many others.”
I’m thinking about this statement …. If I took say Ibuprofen & and took 8 all at once vs spreading over a 24 hour period the side effects would be different. There is something about taking more (80%) & less (20%) that the side effect is the same is not clear. I might be missing something. Maybe time release into our bodies plays a role. Is full dose more effective against estrogen than the 20%.?
I am not advocating for or against AIs as it is purely personal as all our bodies are so very different. Side effects get discussed a lot bit I’m not hearing do much about effectiveness. My doctor could not tell me if Anastrozole was actually working .. said they take it for granted. That not a very scientific or medical studied answer.
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@sequioa you can't really compare dosing of ibuprofen and aromatase inhibitors. I don't know if you saw the study elsewhere in this forum that showed alternate days to be as effective as daily but side effects were the same. I do wonder if dosing will change at some point (to half of what it is now). The Femara studies showed effectiveness with 20% but doubt that will become the practice.
Docs rely on standards of care established by studies. They should refer you to studies, I think, but blood tests aren't very useful to determine effectiveness.