@allwheeldrive I had this same question about neuropathy , constipation, and medications for gut motility. I asked my gastroenterologist this, why something like Motegrity would work if my nerves aren’t functioning correctly. His answer was “it’s complicated”. He was not being sarcastic or dismissive, he was being truthful. I had already read some research articles about gut motility, and it was basically like reading a medical textbook. It’s complicated! As I told my gastroenterologist, I don’t need to know all this, he does! Together we are trying different ideas.
One idea I saw here recently is ColonMax. I’m intrigued, and ordered some from Amazon. I may have wasted another $20, but we’ll see!