1. < Osteoporosis & Bone Health

Tymlos side effects I've encountered

Posted by anniesan @anniesan, Oct 2, 2022

Hi. I started Tymlos in February 2022 and about a month after starting it I began experiencing excruciating muscle spasms, esp in upper thighs and feet, neuropathy, as well as debilitating hip, leg, and back pain. My doctor wanted me to try and stay on it for at least a year, but I absolutely could not go on living with the pain I experienced. I stopped taking the Tymlos completely 6 days ago and all my symptoms have subsided. Has anyone else experienced these side effects while on Tymlos?

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JK | @contentandwell | Dec 5, 2022
In reply to @windyshores "@contentand well, Forteo and Tymlos do not pose the same risks of jawbone necrosis. They build..." + (show)
@windyshores

@contentand well, Forteo and Tymlos do not pose the same risks of jawbone necrosis. They build new bone. Biphosphonates, Prolia and to a lesser extent Evenity are anti-resorptives, which have the potential to affect jawbone as well as femur over time.

In fact, studies have shown that Forteo and Tymlos may actually treat problems in the jawbone or femur that are caused by the other drugs.
https://www.arthritis.org/health-wellness/detail?content=treatment
Forteo May Spur New Bone Growth in the Jaw. Studies show teriparatide, brand name Forteo, may help regrow jawbone loss due to periodontal disease or osteonecrosis. Two studies suggest that the drug teriparatide, or Forteo, may help people who have lost bone in their jaws because of periodontal disease or osteonecrosis.

Just google "Forteo necrosis of jaw" and lots of studies come up. I will leave it to you to see the studies but here are two articles:
https://www.aboutlawsuits.com/forteo-treat-fosamax-jaw-osteonecrosis-13515/
Two new articles published in the New England Journal of Medicine suggest that Forteo (teriparatide) may combat osteonecrosis of the jaw (ONJ) and other fractures caused by bisphosphonate medications, such as Fosamax.

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Thanks, @windyshores I was not as knowledgeable about this as you but I was pretty sure that Forteo (and Tymlos) were not a problem for jawbones as the bisphosphonates are. Your description is very helpful and reassuring as I am just about to finish up two years on Tymlos.
JK

REPLY
txmom | @txmom | Dec 5, 2022
In reply to @contentandwell "@txmom I was not aware that Forteo and Tymlos can affect your jawbone, I thought that..." + (show)
@contentandwell

@txmom I was not aware that Forteo and Tymlos can affect your jawbone, I thought that was just the bisphosphonates. You might want to check on that. I really am not familiar with Evenity. I remember there was something about it that I thought made it inappropriate for me.
JK

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I have seen it listed as a less common side effect as well as back pain. I think that was under Drugs.com.
Thank you,
txmom

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1 reply
windyshores | @windyshores | Dec 5, 2022
In reply to @txmom "I have seen it listed as a less common side effect as well as back pain...." + (show)
@txmom

I have seen it listed as a less common side effect as well as back pain. I think that was under Drugs.com.
Thank you,
txmom

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@txmom could you please provide a link or copy and paste content? I do not understand, given how these drugs work. how they could affect the jawbone, and since I am in the middle of treatment, am curious about your source.

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windyshores | @windyshores | Dec 5, 2022

There is no reference to jaw or dental issues for Forteo on drugs.com. I am posting the list of side effects, common and not common.
https://www.drugs.com/sfx/forteo-side-effects.html
Ditto Tymlos https://www.drugs.com/sfx/tymlos-side-effects.html

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Mentor
Chris Trout, Volunteer Mentor | @artscaping | Dec 5, 2022
In reply to @txmom "Thank you, Chris @Artscaping. However after checking into Alendronate, it lists one side effect as esophagus..." + (show)
@txmom

Thank you, Chris @artscaping. However after checking into Alendronate, it lists one side effect as esophagus problems. I do have problems with my esophagus since I took Boniva several years ago. Still searching! I appreciate your reply.

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Good evening again @txmom. Just wanted to let you know that I started this whole journey with Boniva. It lasted two months and was discontinued because of jaw pain and joint pain. The Alendronate did not create the same kind of side effects as Boniva. In fact, I have no side effects.

Just wanted to clear the air here.
Chris

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txmom | @txmom | Dec 6, 2022

Chris@artscaping, That is very encouraging! Thank you so much. I only took Boniva one time and was in so much esophagus pain that I did not want to repeat it.
Martha

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dianestanley | @dianestanley | Dec 6, 2022
In reply to @txmom "JK @contentandwell After checking on Alendronate, you are right. I also have a bad Esophagus so..." + (show)
@txmom

JK @contentandwell
After checking on Alendronate, you are right. I also have a bad Esophagus so will not be able to take it. And I have a bad jaw bone, so will not be able to take Forteo. I am hoping that a balance of vitamins might help me, but my doctor is really wanting me to take Evenity. I understand it is bad on the jaw bone also. I had an injury from dental work several years ago that has left me with jaw bone pain constantly.

Thank you for your reply. txmom

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I would take the advice of your doctor. I had a broken jaw 1981/teeth wired shut for 8 weeks and had TMJ until I got braces for the second time. Some of my bone in my jaw joint eroded away but stopped. After talking with my doctor who thought Evenity would be good along with an oral surgeon, I had decided to take the risk and get the Evenity. I have bones in my back broken and can only stand for 4-5 mins. I am only 69 so I can't have surgery to fix the problem until I get stronger bones. I want to be almost normal again. The oral surgeon gave me the impression that I know what I went through with my jaw many years ago. If the bone dies, they can use cadaver bone. I have already had a band on one side of my jaw that has worked perfectly. I had decided to get the Evenity and looking forward with hopes of everything turning out good.

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1 reply
sbt54 | @sbt54 | Dec 27, 2022

Has anyone noticed that their diminished side effects from Tymlos start to come back on the first few days of a new pen? I noticed my headaches and hip pain come back for a day or two or three.

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1 reply
windyshores | @windyshores | Dec 28, 2022
In reply to @sbt54 "Has anyone noticed that their diminished side effects from Tymlos start to come back on the..." + (show)
@sbt54

Has anyone noticed that their diminished side effects from Tymlos start to come back on the first few days of a new pen? I noticed my headaches and hip pain come back for a day or two or three.

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No but I refrigerate mine.

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aladdin1 | @aladdin1 | Mar 27, 2023

Hi,
Yesterday I took my third shot of Tymlos. I had severe back pain for 5-10 mins. Has anyone else had this issue? Should I stop taking it?
I am 56 years old and have a good tolerance for pain, but last night was unbearable.
Thanks for any thoughts.

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