@dorota52, that is a very good question to discuss with your oncologist.
Other members like @jbickler @egins1208 @janet4290 also have experience with Zejula (niraparib) as maintenance therapy and have posted in this related discussion.
– Ovarian Cancer: Should I go on Maintenance Therapy? https://connect.mayoclinic.org/discussion/maintenance-therapy/
@tammykl recently started on a clinical trial with immunotherapy and niraparib. Fellow members may be able to share if their treatment protocols have changes with the recent announcements of multiple drug companies to withdraw their respective PARP inhibitors for heavily pretreated ovarian cancer patients.
Here's a copy of the letter that GSK provided to health providers:
https://medinfo.gsk.com/5f95dbd7-245e-4e65-9f36-1a99e28e5bba/57e2a3fa-7b9b-432f-a220-5976a509b534/57e2a3fa-7b9b-432f-a220-5976a509b534_viewable_rendition__v.pdf
It's important to note that the change affects only "treatment of adult patients with advanced ovarian, fallopian tube, or primary peritoneal cancer who have been treated with 3 or more prior chemotherapy regimens and whose cancer is associated with homologous recombination deficiency (HRD) positive status."
"This change does not apply to any other ZEJULA indications including the following for which the USPI remains unchanged:
- for the maintenance treatment of adult patients with advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in a complete or partial response to first-line platinum-based chemotherapy.
- for the maintenance treatment of adult patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in a complete or partial response to platinum-based chemotherapy."
GSK recommends that oncologists discuss options with patients who have already started this protocol.
@dorota52, it sounds like the choice to continue with niraparib is based on the individual and your risk vs benefit. Will you have the opportunity to discuss this with your oncologist soon? How long have you been on niraparib?
"Will you have the opportunity to discuss this with your oncologist soon? How long have you been on niraparib?"
Yes, of course. I have the appointment with my dr on 12 of December. Hovewer, my oncologist doesn't seem to be updated concernig GSK decision for the USA patients. She is confident that I should take it. Therefore, I've asked for a second opinion in the University Hospital in Lausanne (awaiting for appt) . I started Niraparib a week ago. So far no side effects.