I don't have much numbness in my hands but do have a little. I have a little bit of the shakes when using a mouse and my touch typing leaves a lot to be desired but I just keep doing what I can. Writing is another problem. I've pretty much given up cursive and handprint notes, letters and checks. I can still sign my name but it can look pretty rough sometimes 🙂 Just taking it one day at a time and practicing the senior shuffle when walking outside in the winter. I mostly wear pull over shirts with 1/4 zippers or just pull overs so that helps with buttons.