Keep in mind there are generally three ways testosterone plays in prostate cancer.

First and foremost, testosterone produced by the testicles. Lupron is designed to shut that off. How long it does that varies, for some, it is a "short" time. For others, "long."

There are sone who advocate for intermittent ADT as both a way to extend the time to resistance and add to quality of life. You may want to discuss with your medical team after you do your homework on it. If you do, have clear criteria and decision points for stopping, actively monitoring while off ADT and restarting.

Another source of testosterone is the adrenal glands. You may want to discuss doublet or triplet therapy with your medical team, again, after doing your homework, as those regimens include ADT agents which shut down production of testosterone from the adrenal glands.

Finally, there is a possibility if I understand correctly of PCa cells able to produce trans use their own testosterone. If my understanding of that is correct then the doublet or triplet therapy can include agents which stop that.

If you have not already, do an internet search for recent videos by Dr. Kwon. Many, myself included find them informative and useful in formulating a treasure strategy with my medical team.

I echo dirtdancer in this may be a window of a cure though the common thinking is one PCa is advanced is not curable. TgT requires an aggressive approach involving imaging and then an aggressive approach in treatment, thus my comments on doublet or triplet therapy.

If your husband is on Lupron alone, mono therapy then it may be time to have a discussion with his medical team about " it interested in population based medicine, aka standard of care. You want treatment that is specific to his PCa and the outcomes you are seeking, a cure, durable remission...

Kevin