@irenea8 Ugh, here comes that answer again...It depends!

My mucus is sticky and thick by nature, no matter how much water I drink. Before Bronchiectasis, many years before, I lived with chronic ear and sinus infections and my ENT had me take sustained release guaifenesin twice a day. It vastly reduced the frequency of the infections. I had daughters with the same ear/sinus issues, but relatively clear thin mucus. The medication didn't seem to make any difference for them.

Early on in my MAC treatment, the pulmonologist was skeptical about my long term Mucinex use, so I tried stopping, and within days I was having ear pressure and sinuses feeling blocked with thick mucus. It was harder for me to do airway clearance too. Even now, if I skip a day or two, I need extra saline nebs to clear my lungs.

So, I think the answer is that you need to try it, and NAC, to see if it makes any difference for you.

Does anyone else care to share their experience?
Sue