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High or Fluctuating Chromogranin A Level: What does it mean?

Neuroendocrine Tumors (NETs) | Last Active: Jun 18 3:39pm | Replies (184)
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@sanjaykumar1

I have the same issue. I operated for pancreatic tumor in April 22. The CGA level was around 500 in May 22.When tested in July 22,the level was 2200.When last tested in October 22,the CGA level was 3300.The doctor is just saying WAIT and Watch.I contacted 3 oncologist but no one ha solution for it.

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Replies to "I have the same issue. I operated for pancreatic tumor in April 22. The CGA level..."
Teresa, Volunteer Mentor | @hopeful33250 | Nov 24, 2022

Hello @sanjaykumar1,

I can certainly understand your concern about the CGA level rising. It is hard to feel comfortable when there is an unknown factor such as this. If the doctor is testing your CGA level, I'm assuming that the pancreatic tumor was a neuroendocrine tumor or carcinoid (NET). Is my understanding correct?

In reading a previous post you mentioned, "Dota pet scan is ok." This is a good finding as I'm sure you know. There are many different reasons for a CGA level to be higher than normal. Here is an article from the National Institute of Health regarding this:
--Clinical significance of elevated serum chromogranin A levels
https://pubmed.ncbi.nlm.nih.gov/15513336/
If you are currently taking medications that are classified as PPIs (proton pump inhibitors) these can also raise the CGA levels. There are other health factors that can increase these levels as well.

Have you approached your doctor and asked about the reason(s) for these higher levels? If not, please do so. Please also remember that it is alright to seek another opinion if you feel your concerns are not being addressed.

As I see that you live in India I wonder if there is a university medical school, or other major medical center, in your area (or nearby country) where you can seek another opinion? It could be an in-person appointment or a virtual appointment.

When has your current doctor planned a follow-up test or other imaging tests? Have you considered getting another opinion?

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