@jerik, Good evening. Perhaps I can answer that question for you. Yes, you are correct bout the Fosamax (Alendronate) is a weekly pill and Prolia is a twice-a-year injection.

My own experience was not positive when I went on Prolia after 2 years of daily Tymlos injections. Evidently, the amount of medication in a 6-month injection was just too much for my body to handle. The half-life during which the medication is in your body is 3 months. I was used to a small daily dose with the Tymlos injection.

My Mayo endocrinologist figured this out for me. And now I take Alendronate (Fosamax) every Monday morning. I have no side effects.

Also with Prolia, there can be no breaks or drug holidays because of the danger of fractures.

Good luck with your decision.
Chris