@lbo615 -I had a liver biopsy done for PBC and Autoimmune Hepatitis. They put me on Fetanyl, but not all the way under because they needed to talk to me. I think I might of needed to hold my breath a little. They went in through my neck. I felt pressure, but it did not hurt bad. I was a little freaked out, but it all went fine and went pretty fast. Best to you!!