I have had 2 injections of Prolia, one per year. i did not have a rash or UTI. Everyone is different, but I did not have side effects. My physician is an expert in Osteoporosis and recommended Prolia, because I had already been on Fosamax for years, and have osteoporosis in my spine. I did not want to have the drug, but my doctor has more knowledge than I do and I followed her advice. I have not had any bad effects.