I had a lumpectomy and a low enough oncotype that I didn't need chemo. I have been prescribed anastrozole, and have researched the side effects. I am most worried about the mental deterioration and memory loss side effects. I don't know the percentage of women who experience these frightening side-effects. I don't even know how I would know if my cognitive abilities and memory are being affected. It's easier to diagnose the bone loss issue if they happen and I believe there are therapies to deal with bone loss. But I don't like the idea of cognition and memory loss and it seems to be one of the delayed effects that don't happen until you've been on anastrozole for a while. I think the same is true of any AI therapy. I will be discussing this with my oncologist next month. I have not yet had any hair loss and the hot flashes are not bad. I'd get more information from your doctor if I were you. That's what I'm planning to do. Good luck.