@asugent I haven't been reading posts here regularly since my wife passed. In order to stay positive and on point, I'll focus on advice. My wife had "skip metastasis" to the left ovary after 10 months NED. She had it successfully removed and had 2 years of chemo regimens ( GAC x 18 treatments; Onivyde x 12 treatments) neither kept the mets in check. Ascites developed in the last year and added biweekly paracentesis procedures for relief of pressure. I did my own research and found monoclonal antibodies that were being used against ovarian cancer with the same mutations my wife had. While fighting with the hospital and insurance to get approved, I also found that peritoneal chemo can be delivered directly into the abdominal space instead of IV . Look for "hot chemo" and see if it's appropriate. Logically to me (I'm an engineer, not a doctor), since iv chemo doesn't effectively reach all peritoneal tissue, the direct infusion makes sense. By the time I won the arguments by showing proof that there were oncologists doing what logic told me could work, it was too late for my wife. At the first sight of ascites, see about changing regimens and infusion method. Good luck.