Anyone try agmatine sulfate?

Hoping it helps with your neuropathy symptoms @gbny1224. Looks like it was an extremely small study (15 patients) that started in 2012 and ended in 2018 -- https://clinicaltrials.gov/ct2/show/NCT01524666. Also, there is a 2020 writeup on PubMed that looks supportive but only shows data for 11 patients.

-- Evidence for Dietary Agmatine Sulfate Effectiveness in Neuropathies Associated with Painful Small Fiber Neuropathy. A Pilot Open-Label Consecutive Case Series Study:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071502/
Not sure how many members have tried Agmatine Sulfate but hopefully those that have can share their experience with you.

Agmatine Sulfate helps in nitric oxide production, would not the best answer to this to take a high quality nitric oxide supplement? it sounds like dilation of blood vessels for better circulation is the objective.

Welcome @kwcoop, According to the study the objective is to relieve neuropathic pain. I didn't see anything in the study discussing dilation of blood vessels for better circulation, not to say that it isn't a factor. Better circulation is important although I'm not sure it has reduced anyone's pain from neuropathy. Have you read any research on the topic that you can share?

I have read that increased blood flow to extremities results in reduced pain and healing of damaged nerves, I have not seen anything in clinical studies verifying this however. Agmatine Sulfate stimulates the production of nitric acid witch in clinical studies does indeed dialates the vessels, I was seeking if the information was indeed true or if Agmatine had a true pain relief aspect.

Hi all,
I have progressive Idiopathic PN that stings, burns, feels like knife cutting into bone, and occasional bees stinging. Tons of research and several different tests and treatments. EMG twice and ya, its PN. But what can be done about it? This has been going on since 2007 and has progressed up to knees. Walk every day but beginning to lose control of lower leg and foot muscles. Very careful when driving so you know where the Brake pedal is. Its ugly and I feel your pain literally. If you tell somebody how bad it is, they think your crazy because you look ok and can walk. Even my wife says, "Why doesn't it hurt when you’re fishing?" Answer: “my brain is away from my body and intent on coaxing a 4 lb bass into taking a bite!" Got it!" Distraction seems to be about the only relief at times.
So Im sure many or all of you have been researching the net for an answer and if like me, you have 30-40 sites that all have the answer with supplements, diet, exercise, etc. Can you believe the lies these people come up with? Every week you see a new SOLUTION (Pill) FOR PN. Anybody really gotten relief from any of them? Then there are Tens, Rebuilder, and Anodyne electric impulse generators that supposedly match the oscillations of a typical nerve frequency and induce Nitric Oxide production to open the miniscule blood vessels so more oxygen enters the neural paths to heal them.......Well, one study a while back concluded that ANODYNE (inferred light) treatments had no positive effect over the placebo for about 60 participants. So why are they still selling this to PN sufferers? Admittedly, when I use the Anodyne 300 I purchased years ago, it takes the pain down about 5% with a 30minute treatment. However, by the time I treat the second foot, the first foot has already exhibited the original pain intensity. If I do both feet twice, I get about a ½ hour of relief so rather short lived. Then again, my neuropathy has advanced and been doing so for 15 years. Light/new PN cases may be more manageable with Anodyne.
I have reviewed a link to the National Library of Medicine with a study: "Hyperbaric oxygen treatment attenuates neuropathic pain by elevating autophagy flux via inhibiting mTOR pathway. Am J Transl Res. 2017; 9(5): 2629–2638.
Published online 2017 May 15." So this has been known for several years: 5 to be exact. You can google it.
Read through it and a few paragraphs after the technical jargon, you will see some promising comments.
I am going to try this after consulting with an integrative health specialist to get a referral. Will provide some feedback as I see results. Its called Hyperbaric Oxygen Treatment.
Best of luck to all who have this and keep active. “Motion is Lotion” according to my daughter who is a Rn.

Hello @hotfeet, Welcome to Connect. I thought I would post the link to the article you suggested since new members are not able to share links for a short period of time to prevent spammers from advertisers.

-- Hyperbaric oxygen treatment attenuates neuropathic pain by elevating autophagy flux via inhibiting mTOR pathway: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446542/

It's wise to do your own research on treatments. Lots of products out there that claim to be a cure for neuropathy when there is no cure and best case some relief for the symptoms. I like to use the following sites when evaluating new treatments along with finding the latest medical research using Google Scholar (https://scholar.google.com/).

-- FDA's Health Fraud Page
https://www.fda.gov/ForConsumers/ProtectYourself/HealthFraud/ucm539101.htm
-- NIH's - Be an Informed Consumer: https://nccih.nih.gov/health/decisions
-- NIH's - Pain: https://www.nccih.nih.gov/health/pain

There is another discussion on the topic that you may find interesting although it's not related to neuropathy.
-- Hyperbaric Oxygen Therapy for Hepatitis w/Autoimmune Disease

Looking forward to learn if it helps with your symptoms. Best of luck.

@gbny1224 where did you get agmatine from? My understanding is that it is banned at the moment pending further research.

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