I can tell you my twitching is caused by nerves dying and hitting other nerves. It’s like a short in your houses wiring and it hits another wire. Spasms for me go along with the neuropathy. I’ve tried all the home remedies but they didn’t help much. When I was put on clonazepam ( it’s like a long acting Valium. ) It’s stopped most of the twitching and stopped all my spasms.
Do yourself a big favor and find a neurologist who specializes in neuropathy. Most physicians know very little about it. Seeing a regular primary physician for neuropathy is like going to a OBGYN physician to have brain surgery.
Even if you have to travel it is important because that’s all they deal with and can really give you a correct diagnosis and treatment plan.
I sure hope this helps.

My initial neurological symptom due to my Covid vaccine injury was muscle spasms in my toes and stiffness in my calf muscles. My initial EMG at 4.5 months post vaccine was essentially normal. But then 2.5 months later my next EMG showed sensory and motor nerve damage and my ANA titer began increasing. The likely explanation is an autoimmune reaction to the vaccine and autoimmune reactions take time to develop. Most vaccine injured patients begin to improve around 8 months. I'm much better now.

Welcome @kwall1, I moved your message to this existing and related discussion:

- Toe twitching/fasciculations?! https://connect.mayoclinic.org/discussion/toe-twitchingfasciculations

I did this so you can tips from the previous posts and connect with members like @jenniferhunter @frattmaa @pacer3702 @ecann32 @healthyme246 and others.

Since the vaccine I have had spasms and twitching/fasciculations in lower legs; have had all the tests done, MRI, EMG etc. and my last one was 6 weeks ago to test for Small Fibre Neuropathy (SFN); it was a day outpatient visit at a specialized hospital and waiting time was 9 months; I had 12 tubes of blood taken, urine, and chest X-ray and temperature test on legs, feet and hands, and skin biopsy. Results in 2 weeks.
After the results I will have some kind of closure knowing I have done all that I can to find out the cause, even if this test does not show up anything.
Maybe it’s an idea to have that test done….