I took Neulasta only for the 4 cycles of A/C (Andriamicin/Cytoxin?sp) I was advised to take Claritin before the shot (I chose to get the actual shot versus the patch contraption) and then again the next day. I never had any bone pain so I guess I got lucky there. I believe there was also Claritin or an antihistamine equivalent in the infusion mix of drugs (4 bags) the day before.