← Return to Statin discontinued due to neuropathy. What are some alternatives?

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@jeffrapp

As there are many types of peripheral neuropathy, and, as I understand it, the evidence for statins causing PN is present, but not strong, I would appreciate it if those who have discontinued taking statins because of a concern that they might cause PN provide us with studies that support this action. Also, what type of PN were you diagnosed with?
Hyperlipidemia is a strong predictor of heart disease, stokes and other serious problems. Treatment with statins should be discontinued only if there is strong evidence of of serious harm.
BTW, I don't believe nexlizet is covered by MediCare. Paying out of pocket would hurt.

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Replies to "As there are many types of peripheral neuropathy, and, as I understand it, the evidence for..."

Hi Jeff @jeffrapp, My primary care doctor wanted me to take a statin to help lower my cholesterol. In my case, I made the decision not to take it and work on lowering my cholesterol through lifestyle changes. This was shortly after I received my initial diagnosis of idiopathic small fiber PN and started doing some research on what helps and causes. I had neuropathy long before being diagnosed and at one time was on a statin in my 50s for high BP but my meds were changed after I participated in a Mayo Clinic heart study and my diagnosis changed to primary aldosteronism and I was given spironolactone instead of the statin if I remember correctly. I had found articles discussing statin induced neuropathy which I discussed with my doctor as the reason to not take a statin to lower my cholesterol and to figure out how to do that without meds. Here's some of the research I found:

-- The implications of statin induced peripheral neuropathy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103035/
--Statin Neuropathy Masquerading as Diabetic Autoimmune Polyneuropathy
http://care.diabetesjournals.org/content/28/8/2082.1
-- Statins Have Unexpected Effect on Pool of Powerful Brain Cells
https://www.urmc.rochester.edu/news/story/2051/statins-have-unexpected-effect-on-pool-of-powerful-brain-cells.aspx
-- Medication Induced Neuropathy
https://link.springer.com/article/10.1007/s11910-003-0043-8

I stopped taking statins after prescribed back in 2017 because it was causing severe muscle aches. and 3 yrs. later my new cardiologist (who I went to for a "wellness" check up because I had no symptoms and had not been to one in 25 yrs. ) did 6 tests and on the 6th one (camera ) found a triple blockage ( yes no symptoms !!) that was 2 yrs. ago, and since then tried 2 statins, both after approx 6 wks, I developed muscle damage (severe pains and leg cramps.and on top of that, I had to stop exercising which was depressing !! I am now going to get a CK (creatinine kinase ) to see if in fact there is muscle damage. I have now gone back to a non statin, which is only 10mg but did not lower the cholestorol enough, and after 2 wks, muscle pain subsided, so now I added an FDA approved supplement -Cholest 1MD to see if in 3 mth, it has helped ,along with another called Nutrim . So, we will see !!!!

Bergamot has been mentioned as an alternative. Lifestyle change is best.