It depends. Tramadol is metabolized in the liver, so the potential for damage exists. In high doses, it can cause liver damage. In an overdose situation, it can cause acute liver failure. If you already have a compromised liver (fatty liver, cirrhosis or other problems) it is better to choose a different medication. If Tramadol is being prescribed for long term use, a baseline liver panel and periodic blood tests are recommended to watch for problems. People with diabetes, glaucoma, asthma and some other conditions need to be monitored closely when using Tramadol. Interactions between Tramadol, alcohol and certain other drugs can be dangerous.

Sue